Mnemonic for Ankylosing Spondylitis

Extra-articular Manifestations of Ankylosing Spondylitis
6 "A's"
Atlanto-axial subluxation
Anterior uveitis
Apical lung fibrosis
Aortic incompetence
Amyloidosis (kidneys)
Autoimmune bowel disease (UC)

Consider AS in the differential for causes
of aortic regurgitation!!!

Rule of 2s
AS occurs in
0.2% of the general population
2% of HLA-B27 positive individuals
20% of HLA-B27 positive individuals
with affected family member